VASCULAR BIOLOGY Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
نویسندگان
چکیده
1Department of Molecular and Medical Pharmacology, University of California, Los Angeles; 2California Nanosystems Institute, Los Angeles, CA; 3Genentech Inc, South San Francisco, CA; 4Molecular, Cell, and Developmental Biology, University of California, Los Angeles; 5Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles; 6Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington; 7Jonsson Comprehensive Cancer Center, Los Angeles, CA; 8Institute for Molecular Medicine, Los Angeles, CA; and 9David Geffen School of Medicine, University of California, Los Angeles
منابع مشابه
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.
Tumor-infiltrating myeloid cells (TIMs) support tumor growth by promoting angiogenesis and suppressing antitumor immune responses. CSF-1 receptor (CSF1R) signaling is important for the recruitment of CD11b(+)F4/80(+) tumor-associated macrophages (TAMs) and contributes to myeloid cell-mediated angiogenesis. However, the impact of the CSF1R signaling pathway on other TIM subsets, including CD11b(...
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